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獸藥多組分殘留分析技術(shù) 
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9 7 4 8 7 7 7 0 3 3 1 0 6 讀者對(duì)象:本科生、研究生及大專院校、科研單位、質(zhì)檢機(jī)構(gòu)等各類從事食品安全檢測(cè)技術(shù)研究與實(shí)際檢驗(yàn)專業(yè)技術(shù)人員 
全書共分二十章，分別介紹了1苯乙胺（β-受體激動(dòng)劑）類藥物β-Adrenoceptoragonists、2磺胺類藥物Sulfonamides、3氨基糖苷類藥物aminoglycoside、4氯霉素類藥物Chloramphenicol、5β-內(nèi)酰胺類藥物β-lactams、6大環(huán)內(nèi)酯類（macrolides）和林可霉素類藥物、7硝基呋喃類代謝物Nitrofurans、8甾類同化激素anabolicsteroids、9非甾類同化激素類藥物inanabolicsteroids、10糖皮質(zhì)激素類藥物glucocorticoid、11氟喹諾酮類藥物fluoroquinolone、12四環(huán)素類藥物Tetracyclines、13鎮(zhèn)靜劑類藥物sedative、14吡唑酮類藥物Pyrazolone、15喹?f啉類藥物quinoxaline、16硝基咪唑類藥物Nitroimidazole、17苯并咪唑類藥物、18咪唑并噻唑類藥物、19硫脲嘧啶類藥物Thiourea、20聚醚類藥物等200多種獸藥化合物多組分殘留檢測(cè)技術(shù)。每章分別概述了該類化合物理化性質(zhì)和用途、代謝和毒理學(xué)、各國限量以及分析技術(shù)進(jìn)展，重點(diǎn)介紹了一次制備樣品可同時(shí)提取凈化多種獸藥化合物殘留的樣品制備技術(shù)和GC-MS和LC-MS/MS高通量檢測(cè)技術(shù)，這些內(nèi)容充分體現(xiàn)了當(dāng)代國際獸藥化合物殘留分析技術(shù)的研究進(jìn)展。全書內(nèi)容全面、技術(shù)先進(jìn)，既有現(xiàn)代分析技術(shù)詳盡的理論介紹，又有獸藥多組分殘留分析的應(yīng)用實(shí)例；既綜合論述了當(dāng)前國際上獸藥檢測(cè)技術(shù)發(fā)展現(xiàn)狀，又全面介紹了我國獸藥多組分殘留檢測(cè)的最新進(jìn)展。
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目錄
前言 1β-受體激動(dòng)劑類藥物1 1.1概述1 1.1.1理化性質(zhì)與用途1 1.1.2代謝和毒理學(xué)6 1.1.3最大允許殘留限量7 1.1.4殘留分析技術(shù)7 1.2公定方法15 1.2.1河豚魚、鰻魚、烤鰻、牛奶和奶粉中12種β-受體激動(dòng)劑類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法15 參考文獻(xiàn)25 2磺胺類藥物27 2.1概述27 2.1.1理化性質(zhì)與用途27 2.1.2代謝和毒理學(xué)27 2.1.3最大允許殘留限量31 2.1.4殘留分析技術(shù)33 2.2公定方法49 2.2.1河豚魚、鰻魚中18種磺胺殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法49 2.2.2蜂王漿中18種磺胺殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法57 2.2.3畜禽肉中16種磺胺殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法62 2.2.4蜂蜜中16種磺胺殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法67 2.2.5牛奶和奶粉中16種磺胺殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法72 參考文獻(xiàn)79 3氨基糖苷類藥物86 3.1概述86 3.1.1理化性質(zhì)與用途86 3.1.2代謝和毒理學(xué)88 3.1.3最大允許殘留限量89 3.1.4殘留分析技術(shù)90 3.2公定方法100 3.2.1奶粉、牛奶、河豚魚、鰻魚和蜂王漿中鏈霉素、雙氫鏈霉素和卡那霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法100 3.2.2蜂蜜中鏈霉素、雙氫鏈霉素和卡那霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法108 參考文獻(xiàn)110 4氯霉素類藥物115 4.1概述115 4.1.1理化性質(zhì)與用途115 4.1.2代謝和毒理學(xué)116 4.1.3最大允許殘留限量118 4.1.4殘留分析技術(shù)118 4.2公定方法143 4.2.1河豚魚、鰻魚和烤鰻中氯霉素、甲砜霉素和氟苯尼考?xì)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法143 4.2.2可食動(dòng)物肌肉、肝臟和水產(chǎn)品中氯霉素、甲砜霉素和氟苯尼考?xì)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法149 參考文獻(xiàn)153 5β-內(nèi)酰胺類藥物161 5.1概述161 5.1.1理化性質(zhì)與用途161 5.1.2代謝和毒理學(xué)165 5.1.3最大允許殘留限量166 5.1.4殘留分析技術(shù)166 5.2公定方法180 5.2.1畜禽肉中9種青霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法180 5.2.2牛奶和奶粉中9種青霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法187 5.2.3河豚魚和鰻魚中9種青霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法193 5.2.4蜂蜜中6種青霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法198 5.2.5蜂蜜中5種頭孢菌素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法204 5.2.6河豚魚和鰻魚中5種頭孢菌素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法210 5.2.7牛奶和奶粉中4種頭孢菌素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法213 參考文獻(xiàn)216 6大環(huán)內(nèi)酯類和林可胺類藥物220 6.1概述220 6.1.1理化性質(zhì)與用途222 6.1.2代謝和毒理學(xué)223 6.1.3最大允許殘留限量225 6.1.4殘留分析技術(shù)228 6.2公定方法236 6.2.1畜禽肉中9種大環(huán)內(nèi)酯類和林可胺類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法236 6.2.2蜂蜜中8種大環(huán)內(nèi)酯類和林可胺類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法243 6.2.3蜂王漿和蜂王漿凍干粉中8種大環(huán)內(nèi)酯類和林可胺類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法249 6.2.4河豚魚、鰻魚中8種大環(huán)內(nèi)酯類和林可胺類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法255 6.2.5牛奶和奶粉中6種大環(huán)內(nèi)酯類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法261 參考文獻(xiàn)266 7硝基呋喃類代謝物271 7.1概述271 7.1.1理化性質(zhì)與用途271 7.1.2代謝和毒理學(xué)272 7.1.3最大允許殘留限量274 7.1.4殘留分析技術(shù)274 7.2公定方法282 7.2.1動(dòng)物源食品中硝基呋喃類代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法282 參考文獻(xiàn)294 8甾類同化激素類藥物298 8.1概述298 8.1.1理化性質(zhì)與用途298 8.1.2代謝和毒理學(xué)303 8.1.3最大允許殘留限量303 8.1.4殘留分析技術(shù)304 8.2公定方法321 8.2.1牛肝和牛肉中睪酮、表睪酮、孕酮?dú)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法321 8.2.2牛奶和奶粉中醋酸美侖孕酮、醋酸氯地孕酮和醋酸甲地孕酮?dú)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法326 8.2.3牛奶和奶粉中α-群勃龍、β-群勃龍、19-乙烯去甲睪酮和epi-19-乙烯去甲睪酮?dú)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法330 8.2.4牛肌肉、肝、腎中的α-群勃龍、β-群勃龍殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法336 8.2.5牛尿中α-群勃龍、β-群勃龍、19-乙烯去甲睪酮和epi-19-乙烯去甲睪酮?dú)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法340 參考文獻(xiàn)345 9非甾類同化激素類藥物350 9.1概述350 9.1.1理化性質(zhì)與用途350 9.1.2代謝和毒理學(xué)352 9.1.3最大允許殘留限量354 9.1.4殘留分析技術(shù)354 9.2公定方法369 9.2.1牛豬肝腎和肌肉組織中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、雙烯雌酚殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法369 9.2.2牛尿中玉米赤霉醇、己烯雌酚、己烷雌酚、雙烯雌酚殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法376 9.2.3河豚魚、鰻魚和烤鰻中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、雙烯雌酚殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法379 9.2.4牛奶和奶粉中玉米赤霉醇、玉米赤霉酮、己烯雌酚、己烷雌酚、雙烯雌酚殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法384 9.2.5動(dòng)物源性食品中玉米赤霉醇?xì)埩袅康臏y(cè)定液相色譜-串聯(lián)質(zhì)譜法389 參考文獻(xiàn)393 10糖皮質(zhì)激素類藥物398 10.1概述398 10.1.1理化性質(zhì)與用途398 10.1.2代謝和毒理學(xué)401 10.1.3最大允許殘留限量401 10.1.4殘留分析技術(shù)402 10.2公定方法412 10.2.1河豚魚、鰻魚及烤鰻中9種糖皮質(zhì)激素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法412 參考文獻(xiàn)419 11喹諾酮類藥物423 11.1概述423 11.1.1理化性質(zhì)與用途423 11.1.2代謝和毒理學(xué)429 11.1.3最大允許殘留限量430 11.1.4殘留分析技術(shù)433 11.2公定方法447 11.2.1鰻魚及制品中15種喹諾酮類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法447 11.2.2蜂蜜中14種喹諾酮類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法455 11.2.3牛奶和奶粉中7種喹諾酮類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法465 參考文獻(xiàn)471 12四環(huán)素類藥物479 12.1概述479 12.1.1理化性質(zhì)與用途479 12.1.2代謝和毒理學(xué)481 12.1.3最大允許殘留限量482 12.1.4殘留分析技術(shù)483 12.2公定方法497 12.2.1蜂蜜中土霉素、四環(huán)素、金霉素、強(qiáng)力霉素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法497 12.2.2蜂蜜中土霉素、四環(huán)素、金霉素、強(qiáng)力霉素殘留量的測(cè)定液相色譜-紫外檢測(cè)法504 12.2.3可食動(dòng)物肌肉中土霉素、四環(huán)素、金霉素、強(qiáng)力霉素殘留量的測(cè)定液相色譜-紫外檢測(cè)法509 12.2.4河豚魚、鰻魚中土霉素、四環(huán)素、金霉素、強(qiáng)力霉素殘留量的測(cè)定液相色譜-紫外檢測(cè)法512 12.2.5牛奶和奶粉中土霉素、四環(huán)素、金霉素、強(qiáng)力霉素殘留量的測(cè)定液相色譜-紫外檢測(cè)法516 參考文獻(xiàn)521 13鎮(zhèn)靜劑類藥物527 13.1概述527 13.1.1理化性質(zhì)與用途527 13.1.2代謝和毒理學(xué)533 13.1.3最大允許殘留限量534 13.1.4殘留分析技術(shù)535 13.2公定方法549 13.2.1豬腎和肌肉組織、牛奶和奶粉中8種鎮(zhèn)定劑殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法549 參考文獻(xiàn)559 14吡唑酮類藥物564 14.1概述564 14.1.1理化性質(zhì)與用途564 14.1.2代謝和毒理學(xué)566 14.1.3最大允許殘留限量568 14.1.4殘留分析技術(shù)569 14.2公定方法580 14.2.1牛和豬肌肉中安乃近代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法580 14.2.2牛奶和奶粉中安乃近代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法586 參考文獻(xiàn)593 15喹 啉類藥物596 15.1概述596 15.1.1理化性質(zhì)與用途596 15.1.2代謝和毒理學(xué)598 15.1.3最大允許殘留限量601 15.1.4殘留分析技術(shù)601 15.2公定方法614 15.2.1牛、豬肝臟和肌肉中卡巴氧和喹乙醇及代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法614 15.2.2牛奶和奶粉中卡巴氧和喹乙醇代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法619 參考文獻(xiàn)623 16硝基咪唑類藥物627 16.1概述627 16.1.1理化性質(zhì)與用途627 16.1.2代謝和毒理學(xué)629 16.1.3最大允許殘留限量630 16.1.4殘留分析技術(shù)630 16.2公定方法642 16.2.1牛奶和奶粉中甲硝唑、洛硝噠唑、二甲硝唑及其代謝物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法642 16.2.2蜂蜜中甲硝唑、洛硝噠唑、二甲硝咪唑殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法648 16.2.3蜂王漿及凍干粉中9種硝基咪唑類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法653 參考文獻(xiàn)661 17苯并咪唑類藥物665 17.1概述665 17.1.1理化性質(zhì)與用途665 17.1.2代謝和毒理學(xué)669 17.1.3最大允許殘留限量670 17.1.4殘留分析技術(shù)671 17.2公定方法684 17.2.1牛奶和奶粉中5種苯并咪唑類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法684 17.2.2河豚魚、鰻魚和烤鰻中16種苯并咪唑類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法691 參考文獻(xiàn)698 18咪唑駢噻唑類藥物703 18.1概述703 18.1.1理化性質(zhì)與用途703 18.1.2代謝和毒理學(xué)704 18.1.3最大允許殘留限量705 18.1.4殘留分析技術(shù)706 18.2公定方法711 18.2.1牛奶和奶粉中左旋咪唑殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法711 參考文獻(xiàn)717 19硫脲嘧啶類藥物720 19.1概述720 19.1.1理化性質(zhì)與用途720 19.1.2代謝和毒理學(xué)722 19.1.3最大允許殘留限量723 19.1.4殘留分析技術(shù)723 19.2公定方法736 19.2.1牛甲狀腺和牛肉中5種硫脲嘧啶類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法736 19.2.2動(dòng)物源性食品中8種甲狀腺拮抗劑殘留量的測(cè)定高效液相色譜-串聯(lián)質(zhì)譜法742 參考文獻(xiàn)748 20聚醚類藥物751 20.1概述751 20.1.1理化性質(zhì)與用途751 20.1.2代謝和毒理學(xué)754 20.1.3最大允許殘留限量754 20.1.4殘留分析技術(shù)756 20.2公定方法765 20.2.1牛奶和奶粉中6種聚醚類抗生素殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法765 參考文獻(xiàn)773 21阿維菌素類藥物777 21.1概述777 21.1.1理化性質(zhì)與用途777 21.1.2代謝和毒理學(xué)780 21.1.3最大允許殘留限量781 21.1.4殘留分析技術(shù)782 21.2公定方法792 21.2.1牛肝和牛肉中4種阿維菌素類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法792 21.2.2牛奶和奶粉中4種阿維菌素類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法796 21.2.3河豚魚、鰻魚和烤鰻中4種阿維菌素類藥物殘留量的測(cè)定液相色譜-串聯(lián)質(zhì)譜法801 參考文獻(xiàn)805 22獸藥多類別多組分殘留810 22.1概述810 22.1.1前處理方法810 22.1.2測(cè)定方法813 22.2獸藥精確質(zhì)量數(shù)據(jù)庫的建立與碎裂機(jī)理研究815 22.2.1試劑和材料816 22.2.2標(biāo)準(zhǔn)品和儲(chǔ)備溶液816 22.2.3儀器與設(shè)備816 22.2.4液相色譜條件817 22.2.5質(zhì)譜條件817 22.2.6獸藥種類的確定817 22.2.7數(shù)據(jù)庫的構(gòu)建817 22.2.8質(zhì)譜解析及裂解規(guī)律819 22.2.9小結(jié)834 22.3實(shí)驗(yàn)室內(nèi)部方法834 22.3.1豬肉、牛肉和羊肉中55種獸藥多組分殘留測(cè)定液相色譜-串聯(lián)質(zhì)譜法834 22.3.2蜂蜜中40種獸藥多組分殘留測(cè)定液相色譜-四極桿-飛行質(zhì)譜法844 22.3.3奶粉中100種獸藥多組分殘留測(cè)定液相色譜-四極桿-飛行質(zhì)譜法858 參考文獻(xiàn)877 Contents Preface 1β-Agonists1 1.1General Overview1 1.1.1Physicochemical property and pharmaceutical use1 1.1.2Metabolism and toxicology6 1.1.3Maximum residue limits, MRLs7 1.1.4Analytical technology7 1.2Official method15 1.2.1Determination of 12 β-agonists residues in fugu, eel, baked eel, milk and milk powder by LC-MS/MS15 References25 2Sulfonamides27 2.1General overview27 2.1.1Physicochemical property and pharmaceutical use27 2.1.2Metabolism and toxicology 27 2.1.3Maximum residue limits, MRLs31 2.1.4Analytical technology33 2.2Official method49 2.2.1Determination of 18 sulfonamides residues in fugu and eel by LC-MS/MS49 2.2.2Determination of 18 sulfonamide residues in royal jelly by LC-MS/MS57 2.2.3Determination of 16 sulfonamide residues in livestock and poultry muscles by LC-MS/MS62 2.2.4Determination of 16 sulfonamide residues in honey by LC-MS/MS67 2.2.5Determination of 16 sulfonamide residues in milk and milk powder by LC-MS/MS72 References79 3Aminoglycosid86 3.1General Overview86 3.1.1Physicochemical property and pharmaceutical use86 3.1.2Metabolism and toxicology88 3.1.3Maximum residue limits, MRLs89 3.1.4Analytical technology90 3.2Official method100 3.2.1Determination of streptomycin, dihydrostreptomycin and kanamycin residues in milk powder, milk, fugu, eel and royal jelly by LC-MS/MS100 3.2.2Determination of streptomycin, dihydrostreptomycin and kanamycin residues in honey by LC-MS/MS108 References110 4Chloramphenicol115 4.1General Overview115 4.1.1Physicochemical property and pharmaceutical use115 4.1.2Metabolism and toxicology116 4.1.3Maximum residue limits, MRLs118 4.1.4Analytical technology118 4.2Official method143 4.2.1Determination of chloramphenicol, thiamphenicol and florfenicol residues in fugu, eel and bakedeel by LC-MS/MS143 4.2.2Determination of chloramphenicol, thiamphenicol and florfenicol residues in edible animal muscles,liver and aquatic products by LC-MS/MS149 References153 5β-Lactams161 5.1General overview161 5.1.1Physicochemical property and pharmaceutical use161 5.1.2Metabolism and toxicology165 5.1.3Maximum residue limits, MRLs166 5.1.4Analytical technology166 5.2Official method180 5.2.1Determination of 9 penicillin residues in livestock and poultry muscles by LC-MS/MS180 5.2.2Determination of 9 penicillin residues in milk and milk powder by LC-MS/MS187 5.2.3Determination of 9 penicillin residues in fugu and eel by LC-MS/MS193 5.2.4Determination of 6 penicillin residues in honey by LC-MS/MS198 5.2.5Determination of 5 cephalosporin residues in honey by LC-MS/MS204 5.2.6Determination of 5 cephalosporin residues in fugu and eel by LC-MS/MS210 5.2.7Determination of 4 cephalosporin residues in milk and milk powder by LC-MS/MS213 References216 6Macrolides and lincosamides220 6.1General overview220 6.1.1Physicochemical property and pharmaceutical use222 6.1.2Metabolism and toxicology223 6.1.3Maximum residue limits, MRLs225 6.1.4Analytical technology228 6.2Official method236 6.2.1Determination of 9 macrolide and lincosamide residues in livestock and poultry muscles by LC-MS/MS236 6.2.2Determination of 8 macrolide and lincosamide residues in honey by LC-MS/MS243 6.2.3Determination of 8 macrolide residues in royal jelly and lyophilized royal jelly power by LC-MS/MS249 6.2.4Determination of 8 macrolide and lincosamide residues in fugu and eel by LC-MS/MS255 6.2.5Determination of 8 macrolide residues in milk and milk powder by LC-MS/MS261 References266 7Nitrofuran metabolites271 7.1General overview271 7.1.1Physicochemical property and pharmaceutical use271 7.1.2Metabolism and toxicology272 7.1.3Maximum residue limits, MRLs274 7.1.4Analytical technology274 7.2Official method282 7.2.1Determination of nitrofuran metabolite residues in animal original food by LC-MS/MS282 References294 8Anabolic steroids298 8.1General overview298 8.1.1Physicochemical property and pharmaceutical use298 8.1.2Metabolism and toxicology303 8.1.3Maximum residue limits, MRLs303 8.1.4Analytical technology 304 8.2Official method321 8.2.1Determination of testosterone, epi-testosterone and progesterone residues in bovine liver and muscletissues by LC-MS/MS321 8.2.2Determination of melengestrol acetate, chlormadinone acetate and megestrol acetate residues in milkand milk powder by LC-MS/MS326 8.2.3Determination of α-trenbolone, β-trenbolone, nortestosterone and epi-nortestosterone residues in milkand milk powder by LC-MS/MS330 8.2.4Determination of α-trenbolone, β-trenbolone residues in bovine muscle, liver and kidney byLC-MS/MS336 8.2.5Determination of α-trenbolone, β-trenbolone, nortestosterone and epi-nortestosterone residues in bovineurine by LC-MS/MS340 References345 9Inanabolic steroids350 9.1General overview350 9.1.1Physicochemical property and pharmaceutical use350 9.1.2Metabolism and toxicology352 9.1.3Maximum residue limits, MRLs354 9.1.4Analytical technology354 9.2Official method369 9.2.1Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol multi-residuesin bovine and porcine liver, kidney and muscle by LC-MS/MS369 9.2.2Determination of zearalanol, diethylstilbestrol, hexestrol and dienoestrol multi-residues in bovine urineby LC-MS/MS376 9.2.3Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol residues in fugu,eels and baked eel by LC-MS/MS379 9.2.4Determination of zearalanol, zearalanone, diethylstilbestrol, hexestrol and dienoestrol residues in milkand milk powder by LC-MS/MS384 9.2.5Determination of zeranol residues in animal original food by LC-MS/MS389 References393 10Glucocorticoids398 10.1General overview398 10.1.1Physicochemical property and pharmaceutical use398 10.1.2Metabolism and toxicology401 10.1.3Maximum residue limits, MRLs401 10.1.4Analytical technology402 10.2Official method412 10.2.1Determination of 9 glucocorticoid residues in fugu, eel and baked eel by LC-MS/MS412 References419 11Quinolones423 11.1General overview423 11.1.1Physicochemical property and pharmaceutical use423 11.1.2Metabolism and toxicology429 11.1.3Maximum residue limits, MRLs430 11.1.4Analytical technology433 11.2Official method447 11.2.1Determination of 15 fluoroquinolone residues in eel and eel product by LC-MS/MS447 11.2.2Determination of 14 fluoroquinolone residues in honey by LC-MS/MS455 11.2.3Determination of 7 fluoroquinolone residues in milk and milk powder by LC-MS/MS465 References471 12Tetracyclines479 12.1General overview479 12.1.1Physicochemical property and pharmaceutical use479 12.1.2Metabolism and toxicology481 12.1.3Maximum residue limits, MRLs482 12.1.4Analytical technology483 12.2Official method497 12.2.1Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in honeyby LC-MS/MS497 12.2.2Determination of oxytetracycline,tetracycline, chlortetracycline and doxycycline residues in honeyby LC-UV504 12.2.3Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in edibleanimal muscles by LC-UV509 12.2.4Determination of oxytetracycline, tetracycline, chlortetracycline, doxycycline residues in fugu andeel by LC-UV512 12.2.5Determination of oxytetracycline, tetracycline, chlortetracycline, and doxycycline residues in milkand milk powder by LC-UV516 References521 13Sedatives527 13.1General overview527 13.1.1Physicochemical property and pharmaceutical use527 13.1.2Metabolism and toxicology533 13.1.3Maximum residue limits, MRLs534 13.1.4Analytical technology535 13.2Official method549 13.2.1Determination of 8 sedative residues in porcine kidney, muscle tissues, milk and milk powderby LC-MS/MS549 References559 14Pyrazolones564 14.1General overview564 14.1.1Physicochemical property and pharmaceutical use564 14.1.2Metabolism and toxicology566 14.1.3Maximum residue limits, MRLs568 14.1.4Analytical technology569 14.2Official method580 14.2.1Determination of metabolite residues of dipyrone in bovine and porcine muscle tissues byLC-MS/MS580 14.2.2Determination of metabolite residues of dipyrone in milk and milk powder by LC-MS/MS586 References593 15Quinoxalines596 15.1General overview596 15.1.1Physicochemical property and pharmaceutical use596 15.1.2Metabolism and toxicology598 15.1.3Maximum residue limits, MRLs601 15.1.4Analytical technology601 15.2Official method614 15.2.1Determination of the residues of carbadox, olaquindox and related metabolites in bovine and porcineliver and muscle tissues by LC-MS/MS614 15.2.2Determination of the residues of metabolites of carbadox and olaquindox in milk and milkpowder by LC-MS/MS619 References623 16Nitroimidazoles627 16.1General overview627 16.1.1Physicochemical property and pharmaceutical use627 16.1.2Metabolism and toxicology629 16.1.3Maximum residue limits, MRLs630 16.1.4Analytical technology630 16.2Official method642 16.2.1Determination of metronidazole, ronidazole, dimetridazole residues in milk and milk powder byLC-MS/MS642 16.2.2Determination of metronidazole, ronidazole and dimetridazole residues in honey by LC-MS/MS648 16.2.3Determination of nitroimidazole residues in royal jelly and lyophilized royal jelly power by LC-MS/MS653 References661 17Benzimidazoles665 17.1General overview665 17.1.1Physicochemical property and pharmaceutical use665 17.1.2Metabolism and toxicology669 17.1.3Maximum residue limits, MRLs670 17.1.4Analytical technology671 17.2Official method684 17.2.1Determination of 5 benzimidazoles residues in milk and milk powder by LC-MS/MS684 17.2.2Determination of 16 benzimidazoles residues in fugu, eel and baked eel by LC-MS/MS691 References698 18Imidazothiazoles703 18.1General overview703 18.1.1Physicochemical property and pharmaceutical use703 18.1.2Metabolism and toxicology704 18.1.3Maximum residue limits, MRLs705 18.1.4Analytical technology706 18.2Official method711 18.2.1Determination of levamisole residues in milk and milk powder by LC-MS/MS711 References717 19Thioureas720 19.1General overview720 19.1.1Physicochemical property and pharmaceutical use720 19.1.2Metabolism and toxicology722 19.1.3Maximum residue limits, MRLs723 19.1.4Analytical technology723 19.2Official method736 19.2.1Determination of 5 thiourea residues in bovine thyroid and muscles by LC-MS/MS736 19.2.2Determination of 8 thyreostat residues in foodstuffs of animal origin by LC-MS/MS742 References748 20Polyethers751 20.1General overview751 20.1.1Physicochemical property and pharmaceutical use751 20.1.2Metabolism and toxicology754 20.1.3Maximum residue limits, MRLs754 20.1.4Analytical technology756 20.2Official method765 20.2.1Determination of 6 polyether antibiotics residues in milk and milk powder by LC-MS/MS765 References773 21Avermectins777 21.1General overview777 21.1.1Physicochemical property and pharmaceutical use777 21.1.2Metabolism and toxicology780 21.1.3Maximum residue limits, MRLs781 21.1.4Analytical technology782 21.2Official method792 21.2.1Determination of 4 avermectin residues in bovine liver and muscle tissues by LC-MS/MS792 21.2.2Determination of 4 avermectin residues in milk and milk powder by LC-MS/MS796 21.2.3Determination of 4 avermectin residues in fugu, eel and baked eel by LC-MS/MS801 References805 22Multi-classes of veterinary drug residues810 22.1General overview810 22.1.1Pretreatment method810 22.1.2Analytical method813 22.2Construction of accurate mass data bank and the research of fragmentation mechanism815 22.2.1Reagent and material816 22.2.2Standard and stock solution816 22.2.3Instrument816 22.2.4LC conditions817 22.2.5MS conditions817 22.2.6Confirmation of target drugs817 22.2.7Data bank construction817 22.2.8Mass spectra interpretation and fragmentation mechanism819 22.2.9Summary834 22.3Non-official method834 22.3.1Determination of 55 veterinary drug residues in pork, beef and mutton by LC-MS/MS834 22.3.2Determination of 40 veterinary drug residues in honey by LC-Q-TOFMS844 22.3.3Determination of 100 veterinary drug residues in milk powder by LC-Q-TOFMS858 References877
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