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臨床大數(shù)據(jù)分析與挖掘——基于Python和機器學(xué)習(xí)的臨床決策 讀者對象:醫(yī)學(xué)方向的數(shù)據(jù)科學(xué)與大數(shù)據(jù)、智能醫(yī)療器械等專業(yè)的學(xué)生或教師。
本書不僅講解了機器學(xué)習(xí)基本原理和基本方法,而且通過大量醫(yī)療領(lǐng)域的案例實現(xiàn)對醫(yī)療健康數(shù)據(jù)的處理和分析,能夠在很大程度上輔助醫(yī)護人員進行臨床決策。通過本書學(xué)習(xí),讀者不僅能夠掌握機器學(xué)習(xí)算法建模前的數(shù)據(jù)準(zhǔn)備、篩選構(gòu)造機器學(xué)習(xí)算法指標(biāo)的特征工程、不同類別的機器學(xué)習(xí)算法,還能夠掌握臨床診療數(shù)據(jù)、電子病歷檔案數(shù)據(jù)及影像數(shù)據(jù)等多源異構(gòu)數(shù)據(jù)的處理方法,以及醫(yī)療圖像、文本等數(shù)據(jù)的讀取、預(yù)處理、可視化等知識。同時,本書還介紹了具有開源、去編程化的TipDM 數(shù)據(jù)挖掘建模平臺,通過拖曳的圖形化操作就能實現(xiàn)數(shù)據(jù)分析的全流程。本書可以作為醫(yī)學(xué)類院校數(shù)據(jù)科學(xué)與大數(shù)據(jù)技術(shù)專業(yè)的核心課程教材,以及醫(yī)工專業(yè)的專業(yè)核心課程或選修課程教材。在此基礎(chǔ)上,還可以作為臨床、口腔、醫(yī)技、檢驗、影像、公共衛(wèi)生等醫(yī)學(xué)類專業(yè)進階層次的專業(yè)限選課程或拓展課程的教材。
孫麗萍,上海健康醫(yī)學(xué)院醫(yī)療器械學(xué)副院長、教授。中國自動化學(xué)會常務(wù)委員、中國機器人大賽醫(yī)療服務(wù)機器人項目負(fù)責(zé)人、RoboCup Junior機器人世界杯中國賽醫(yī)療服務(wù)機器人項目負(fù)責(zé)人、中國服務(wù)機器人大賽負(fù)責(zé)人。中國科技部生產(chǎn)力促進中心服務(wù)機器人專業(yè)委員會委員。中國衛(wèi)生信息與健康醫(yī)療大數(shù)據(jù)學(xué)會醫(yī)療健康專委會副秘書長。人工智能醫(yī)療器械標(biāo)準(zhǔn)化制定組專家。
第1 章機器學(xué)習(xí) ··············································································································1
1.1 機器學(xué)習(xí)簡介·······································································································1 1.1.1 機器學(xué)習(xí)的概念······························································································1 1.1.2 機器學(xué)習(xí)的應(yīng)用領(lǐng)域························································································1 1.2 機器學(xué)習(xí)通用流程································································································2 1.2.1 目標(biāo)分析·······································································································2 1.2.2 數(shù)據(jù)準(zhǔn)備·······································································································3 1.2.3 特征工程·······································································································4 1.2.4 模型訓(xùn)練與調(diào)優(yōu)······························································································5 1.2.5 性能度量與模型應(yīng)用························································································6 1.3 Python 機器學(xué)習(xí)工具庫簡介·················································································6 1.3.1 數(shù)據(jù)準(zhǔn)備相關(guān)工具庫························································································6 1.3.2 數(shù)據(jù)可視化相關(guān)工具庫·····················································································7 1.3.3 模型訓(xùn)練與評估相關(guān)工具庫···············································································8 小結(jié)····························································································································9 課后習(xí)題 ··················································································································.10 第 2 章數(shù)據(jù)準(zhǔn)備 ···········································································································.12 2.1 數(shù)據(jù)質(zhì)量校驗····································································································.12 2.1.1 一致性校驗·································································································.12 2.1.2 缺失值校驗·································································································.15 2.1.3 異常值校驗·································································································.17 2.2 數(shù)據(jù)分布與趨勢探查·························································································.18 2.2.1 分布分析····································································································.18 2.2.2 對比分析····································································································.22 2.2.3 描述性統(tǒng)計分析···························································································.25 2.2.4 周期性分析·································································································.28 2.2.5 貢獻度分析·································································································.29 2.2.6 相關(guān)性分析·································································································.31 VIII 2.3 數(shù)據(jù)清洗···········································································································.35 2.3.1 缺失值處理·································································································.35 2.3.2 異常值處理·································································································.38 2.4 數(shù)據(jù)合并···········································································································.39 2.4.1 數(shù)據(jù)堆疊····································································································.39 2.4.2 主鍵合并····································································································.43 小結(jié)·························································································································.45 課后習(xí)題 ··················································································································.45 第 3 章特征工程 ···········································································································.48 3.1 特征變換···········································································································.48 3.1.1 標(biāo)準(zhǔn)化·······································································································.48 3.1.2 獨熱編碼····································································································.54 3.1.3 離散化·······································································································.55 3.2 特征選擇···········································································································.58 3.2.1 子集搜索與評價···························································································.58 3.2.2 過濾式選擇·································································································.59 3.2.3 包裹式選擇·································································································.59 3.2.4 嵌入式選擇與L1 范數(shù)正則化···········································································.60 3.2.5 稀疏表示與字典學(xué)習(xí)·····················································································.61 小結(jié)·························································································································.63 課后習(xí)題 ··················································································································.63 第 4 章有監(jiān)督學(xué)習(xí) ········································································································.66 4.1 有監(jiān)督學(xué)習(xí)簡介································································································.66 4.2 性能度量···········································································································.66 4.2.1 分類任務(wù)性能度量························································································.66 4.2.2 回歸任務(wù)性能度量························································································.68 4.3 線性模型···········································································································.69 4.3.1 線性模型簡介······························································································.69 4.3.2 線性回歸····································································································.69 4.3.3 邏輯回歸····································································································.72 4.4 k 近鄰分類········································································································.75 4.5 決策樹··············································································································.78 4.5.1 決策樹簡介·································································································.78 4.5.2 ID3 算法·····································································································.79 4.5.3 C4.5 算法····································································································.81 4.5.4 CART 算法··································································································.83 4.6 支持向量機·······································································································.86 4.6.1 支持向量機簡介···························································································.86 4.6.2 線性支持向量機···························································································.87 4.6.3 非線性支持向量機························································································.91 4.7 樸素貝葉斯·······································································································.94 4.8 神經(jīng)網(wǎng)絡(luò)···········································································································.98 4.8.1 神經(jīng)網(wǎng)絡(luò)介紹······························································································.98 4.8.2 BP 神經(jīng)網(wǎng)絡(luò)································································································.99 4.9 集成學(xué)習(xí)···········································································································104 4.9.1 Bagging ······································································································104 4.9.2 Boosting ·····································································································106 4.9.3 Stacking ······································································································115 小結(jié)·························································································································116 課后習(xí)題 ··················································································································116 第 5 章無監(jiān)督學(xué)習(xí) ········································································································118 5.1 無監(jiān)督學(xué)習(xí)簡介································································································118 5.2 降維··················································································································118 5.2.1 PCA ··········································································································118 5.2.2 核化線性降維······························································································121 5.3 聚類任務(wù)···········································································································123 5.3.1 聚類性能度量指標(biāo)························································································124 5.3.2 距離計算····································································································125 5.3.3 原型聚類····································································································126 5.3.4 密度聚類····································································································137 5.3.5 層次聚類····································································································139 小結(jié)·························································································································142 課后習(xí)題 ··················································································································142 第 6 章智能推薦 ···········································································································144 6.1 智能推薦簡介····································································································144 6.1.1 推薦系統(tǒng)····································································································144 6.1.2 智能推薦的應(yīng)用···························································································144 6.2 推薦系統(tǒng)性能度量·····························································································146 6.2.1 離線實驗評價指標(biāo)························································································146 6.2.2 用戶調(diào)查評價指標(biāo)························································································148 6.2.3 在線實驗評價指標(biāo)························································································149 6.3 基于關(guān)聯(lián)規(guī)則的推薦技術(shù)··················································································149 6.3.1 關(guān)聯(lián)規(guī)則和頻繁項集·····················································································150 6.3.2 Apriori 算法·································································································150 6.3.3 FP-Growth 算法····························································································154 6.4 基于協(xié)同過濾的推薦技術(shù)··················································································159 6.4.1 基于用戶的協(xié)同過濾·····················································································159 6.4.2 基于物品的協(xié)同過濾·····················································································163 小結(jié)·························································································································166 課后習(xí)題 ··················································································································167 第 7 章醫(yī)療保險的欺詐發(fā)現(xiàn) ··························································································169 7.1 目標(biāo)分析···········································································································169 7.1.1 背景··········································································································169 7.1.2 數(shù)據(jù)說明····································································································170 7.1.3 分析目標(biāo)····································································································171 7.2 數(shù)據(jù)準(zhǔn)備···········································································································172 7.2.1 描述性統(tǒng)計分析···························································································172 7.2.2 數(shù)據(jù)清洗····································································································172 7.2.3 分析投保人和醫(yī)療機構(gòu)的信息·········································································173 7.3 特征工程···········································································································177 7.3.1 特征選擇····································································································177 7.3.2 特征變換····································································································178 7.4 模型訓(xùn)練···········································································································182 7.5 性能度量···········································································································184 7.5.1 結(jié)果分析····································································································184 7.5.2 聚類性能度量······························································································188 小結(jié)·························································································································190 第 8 章中醫(yī)證型關(guān)聯(lián)規(guī)則分析 ······················································································191 8.1 目標(biāo)分析···········································································································191 8.1.1 背景··········································································································191 8.1.2 數(shù)據(jù)說明····································································································191 8.1.3 分析目標(biāo)····································································································192 8.2 數(shù)據(jù)準(zhǔn)備···········································································································193 8.2.1 數(shù)據(jù)獲取····································································································193 8.2.2 數(shù)據(jù)清洗····································································································195 8.3 特征工程···········································································································196 8.3.1 特征選擇····································································································196 8.3.2 特征變換····································································································197 8.4 模型訓(xùn)練···········································································································201 8.5 性能度量···········································································································202 8.5.1 結(jié)果分析····································································································203 8.5.2 模型應(yīng)用····································································································204 小結(jié)·························································································································204 第 9 章糖尿病遺傳風(fēng)險預(yù)測 ··························································································205 9.1 目標(biāo)分析···········································································································205 9.1.1 背景··········································································································205 9.1.2 數(shù)據(jù)說明····································································································206 9.1.3 分析目標(biāo)····································································································207 9.2 數(shù)據(jù)準(zhǔn)備···········································································································207 9.2.1 數(shù)據(jù)探索····································································································207 9.2.2 數(shù)據(jù)清洗····································································································209 9.3 特征工程···········································································································209 9.4 模型構(gòu)建···········································································································211 9.4.1 交叉驗證····································································································211 9.4.2 模型訓(xùn)練····································································································213 9.5 性能度量···········································································································214 9.5.1 結(jié)果分析····································································································214 9.5.2 模型評價····································································································216 小結(jié)·························································································································216 第 10 章基于深度殘差神經(jīng)網(wǎng)絡(luò)的皮膚癌檢測································································217 10.1 目標(biāo)分析·········································································································217 10.1.1 背景·········································································································217 10.1.2 圖像數(shù)據(jù)說明·····························································································218 10.1.3 分析方法與過程··························································································219 10.2 圖像數(shù)據(jù)預(yù)處理······························································································219 10.2.1 圖像預(yù)處理································································································219 10.2.2 查看處理后的圖像·······················································································222 10.3 模型構(gòu)建·········································································································223 10.3.1 卷積神經(jīng)網(wǎng)絡(luò)(CNN) ················································································223 10.3.2 殘差網(wǎng)絡(luò)(Residual Network) ·······································································226 10.3.3 ImageDataGenerator 參數(shù)說明·········································································228 10.3.4 訓(xùn)練深度殘差神經(jīng)網(wǎng)絡(luò)模型···········································································229 10.4 性能度量·········································································································231 10.4.1 性能分析···································································································231 10.4.2 結(jié)果分析···································································································232 小結(jié)·························································································································234 第 11 章基于 TipDM 數(shù)據(jù)挖掘建模平臺實現(xiàn)醫(yī)療保險的欺詐發(fā)現(xiàn)··································236 11.1 TipDM 數(shù)據(jù)挖掘建模平臺················································································236 11.1.1 首頁·········································································································237 11.1.2 數(shù)據(jù)源······································································································238 11.1.3 工程·········································································································239 11.1.4 系統(tǒng)組件···································································································240 11.1.5 TipDM 數(shù)據(jù)挖掘建模平臺的本地化部署···························································241 11.2 快速構(gòu)建醫(yī)療保險的欺詐發(fā)現(xiàn)工程··································································243 11.2.1 獲取數(shù)據(jù)···································································································244 11.2.2 數(shù)據(jù)準(zhǔn)備···································································································247 11.2.3 特征工程···································································································250 11.2.4 模型訓(xùn)練···································································································253 小結(jié)·························································································································255 參考文獻 ·························································································································256
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