Contributors. . ix

Preface. . xiii

SECTION I

INTRODUCTION TO NEUROLOGY

1 Approach to the Patient with Neurologic Disease. . 2

Daniel H. Lowenstein, Joseph B. Martin,

Stephen L. Hauser

2 The Neurologic Screening Exam. . .. 11

Daniel H. Lowenstein

3 Video Atlas of the Detailed Neurologic

Examination. . .. 12

Martin A. Samuels

4 Neuroimaging in Neurologic Disorders. . 13

William P. Dillon

5 Atlas of Neuroimaging. . 27

Andre D. Furtado, William P. Dillon

6 Electrodiagnostic Studies of Nervous System

Disorders: EEG, Evoked Potentials, and EMG. . 71

Michael J. Aminoff

7 Technique of Lumbar Puncture. . 80

Elizabeth Robbins, Stephen L. Hauser

SECTION II

CLINICAL MANIFESTATIONS OF

NEUROLOGIC DISEASE

8 Pain: Pathophysiology and Management. . 88

James P. Rathmell, Howard L. Fields

9 Headache. . 100

Peter J. Goadsby, Neil H. Raskin

10 Back and Neck Pain. . 107

John W. Engstrom, Richard A. Deyo

11 Syncope. . .. 125

Roy Freeman

12 Dizziness and Vertigo. . .. 135

Mark F. Walker, Robert B. Daroff

13 Fatigue. . 140

Jeffrey M. Gelfand, Vanja C. Douglas

14 Neurologic Causes of Weakness and Paralysis. . 144

Michael J. Aminoff

15 Numbness, Tingling, and Sensory Loss. . 150

Michael J. Aminoff

16 Gait and Balance Disorders. . 157

Lewis Sudarsky

17 Video Library of Gait Disorders. . 163

Gail Kang, Nicholas B. Galifianakis, Michael

D. Geschwind

18 Confusion and Delirium. . 164

S. Andrew Josephson, Bruce L. Miller

19 Coma. . .. 171

Allan H. Ropper

20 Examination of the Comatose Patient. . 181

S. Andrew Josephson

21 Dementia. . 182

William W. Seeley, Bruce L. Miller

22 Aphasia, Memory Loss, and Other Focal

Cerebral Disorders. . 191

M.-Marsel Mesulam

23 Primary Progressive Aphasia, Memory Loss,

and Other Focal Cerebral Disorders. . 204

Maria Luisa Gorno-Tempini, Jennifer Ogar,

Joel Kramer, Bruce L. Miller, Gil Rabinovici,

Maria Carmela Tartaglia

24 Sleep Disorders. . 205

Charles A. Czeisler, Thomas E. Scammell,

Clifford B. Saper

25 Disorders of the Eye. . 221

Jonathan C. Horton

26 Use of the Hand-Held Ophthalmoscope. . 245

Homayoun Tabandeh, Morton F. Goldberg

27 Video Library of Neuro-Ophthalmology. . 253

Shirley H. Wray

28 Disorders of Smell and Taste. . 255

Richard L. Doty, Steven M. Bromley

29 Disorders of Hearing. . 264

Anil K. Lalwani

SECTION III

DISEASES OF THE NERVOUS SYSTEM

30 Biology of Neurologic Diseases. . . . . . . . . . . . . . . . 278

Stephen L. Hauser, Stanley B. Prusiner,

M. Flint Beal

31 Seizures and Epilepsy. . . . . . . . . . . . . . . . . . . . . . . .297

Daniel H. Lowenstein

32 Cerebrovascular Diseases. . . . . . . . . . . . . . . . . . . . . 323

Wade S. Smith, S. Claiborne Johnston,

J. Claude Hemphill

33 Neurologic Critical Care, Including

Hypoxic-Ischemic Encephalopathy, and

Subarachnoid Hemorrhage. . . . . . . . . . . . . . . . . . .361

J. Claude Hemphill, III, Wade S. Smith,

Daryl R. Gress

34 Migraine and Other Primary Headache

Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .376

Peter J. Goadsby, Neil H. Raskin

35 Alzheimers Disease and Other Dementias. . . . . .392

William W. Seeley, Bruce L. Miller

36 Parkinsons Disease and Other Movement

Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .408

C. Warren Olanow, Anthony H.V. Schapira,

Jose A. Obeso

37 Ataxic Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . .435

Roger N. Rosenberg

38 Classification of the Spinocerebellar Ataxias. . . . .443

Roger N. Rosenberg

39 Amyotrophic Lateral Sclerosis and Other Motor

Neuron Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . .449

Robert H. Brown, Jr.

40 Prion Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .459

Stanley B. Prusiner, Bruce L. Miller

41 Disorders of the Autonomic Nervous System. . . .469

Phillip A. Low, John W. Engstrom

42 Trigeminal Neuralgia, Bells Palsy, and Other

Cranial Nerve Disorders . . . . . . . . . . . . . . . . . . . . .481

M. Flint Beal, Stephen L. Hauser

43 Diseases of the Spinal Cord. . . . . . . . . . . . . . . . . . . 490

Stephen L. Hauser, Allan H. Ropper

44 Concussion and Other Traumatic Brain

Injuries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .505

Allan H. Ropper

45 Multiple Sclerosis and Other Demyelinating

Diseases

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .513

Stephen L. Hauser, Douglas S. Goodin

46 Meningitis, Encephalitis, Brain Abscess,

and Empyema . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .533

Karen L. Roos, Kenneth L. Tyler

47 Chronic and Recurrent Meningitis. . . . . . . . . . . . .568

Walter J. Koroshetz, Avindra Nath

48 HIV Neurology. . . . . . . . . . . . . . . . . . . . . . . . . . . . .577

Anthony S. Fauci, H. Clifford Lane

49 Primary and Metastatic Tumors of the

Nervous System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 591

Lisa M. DeAngelis, Patrick Y. Wen

50 Paraneoplastic Neurologic Syndromes

and Autoimmune Encephalitis. . . . . . . . . . . . . . . .606

Josep Dalmau, Myrna R. Rosenfeld

51 Anterior Pituitary Tumor Syndromes . . . . . . . . . .615

Shlomo Melmed, J. Larry Jameson

52 Disorders of the Neurohypophysis. . . . . . . . . . . . .635

Gary L. Robertson

53 Peripheral Neuropathy. . . . . . . . . . . . . . . . . . . . . . . 648

Anthony A. Amato, Richard J. Barohn

54 Guillain-Barré Syndrome and Other

Immune-Mediated Neuropathies. . . . . . . . . . . . . .681

Stephen L. Hauser, Anthony A. Amato

55 Myasthenia Gravis and Other Diseases of

the Neuromuscular Junction. . . . . . . . . . . . . . . . . . 691

Daniel B. Drachman, Anthony A. Amato

56 Muscular Dystrophies and Other Muscle

Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .700

Anthony A. Amato, Robert H. Brown, Jr.

57 Polymyositis, Dermatomyositis, and

Inclusion Body Myositis. . . . . . . . . . . . . . . . . . . . . .730

Marinos C. Dalakas

58 Special Issues in Inpatient Neurologic

Consultation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .742

S. Andrew Josephson, Martin A. Samuels

SECTION IV

CHRONIC FATIGUE SYNDROME

59 Chronic Fatigue Syndrome. . . . . . . . . . . . . . . . . . .752

Gijs Bleijenberg, Jos W. M. van der Meer

SECTION V

PSYCHIATRIC DISORDERS

60 Biology of Psychiatric Disorders. . .. 758

Robert O. Messing, Eric J. Nestler

61 Mental Disorders. . .. 765

Victor I. Reus

62 Neuropsychiatric Illnesses in War Veterans. . 788

Charles W. Hoge

SECTION VI

ALCOHOLISM AND DRUG DEPENDENCY

63 Alcohol and Alcoholism. . 798

Marc A. Schuckit

64 Opioid-Related Disorders. . 807

Thomas R. Kosten, Colin N. Haile

65 Cocaine and Other Commonly Abused

Drugs. . 813

Nancy K. Mello, Jack H. Mendelson

66 Nicotine Addiction. . .. . 821

David M. Burns

Appendix

Laboratory Values of Clinical Importance. . .. 827

Alexander Kratz, Michael A. Pesce,

Robert C. Basner, Andrew J. Einstein

Review and Self-Assessment. . 849

Charles M. Wiener, Cynthia D. Brown,

Brian Houston