Contributors. . ix
Preface. . xiii
SECTION I
INTRODUCTION TO NEUROLOGY
1 Approach to the Patient with Neurologic Disease. . 2
Daniel H. Lowenstein, Joseph B. Martin,
Stephen L. Hauser
2 The Neurologic Screening Exam. . .. 11
Daniel H. Lowenstein
3 Video Atlas of the Detailed Neurologic
Examination. . .. 12
Martin A. Samuels
4 Neuroimaging in Neurologic Disorders. . 13
William P. Dillon
5 Atlas of Neuroimaging. . 27
Andre D. Furtado, William P. Dillon
6 Electrodiagnostic Studies of Nervous System
Disorders: EEG, Evoked Potentials, and EMG. . 71
Michael J. Aminoff
7 Technique of Lumbar Puncture. . 80
Elizabeth Robbins, Stephen L. Hauser
SECTION II
CLINICAL MANIFESTATIONS OF
NEUROLOGIC DISEASE
8 Pain: Pathophysiology and Management. . 88
James P. Rathmell, Howard L. Fields
9 Headache. . 100
Peter J. Goadsby, Neil H. Raskin
10 Back and Neck Pain. . 107
John W. Engstrom, Richard A. Deyo
11 Syncope. . .. 125
Roy Freeman
12 Dizziness and Vertigo. . .. 135
Mark F. Walker, Robert B. Daroff
13 Fatigue. . 140
Jeffrey M. Gelfand, Vanja C. Douglas
14 Neurologic Causes of Weakness and Paralysis. . 144
Michael J. Aminoff
15 Numbness, Tingling, and Sensory Loss. . 150
Michael J. Aminoff
16 Gait and Balance Disorders. . 157
Lewis Sudarsky
17 Video Library of Gait Disorders. . 163
Gail Kang, Nicholas B. Galifianakis, Michael
D. Geschwind
18 Confusion and Delirium. . 164
S. Andrew Josephson, Bruce L. Miller
19 Coma. . .. 171
Allan H. Ropper
20 Examination of the Comatose Patient. . 181
S. Andrew Josephson
21 Dementia. . 182
William W. Seeley, Bruce L. Miller
22 Aphasia, Memory Loss, and Other Focal
Cerebral Disorders. . 191
M.-Marsel Mesulam
23 Primary Progressive Aphasia, Memory Loss,
and Other Focal Cerebral Disorders. . 204
Maria Luisa Gorno-Tempini, Jennifer Ogar,
Joel Kramer, Bruce L. Miller, Gil Rabinovici,
Maria Carmela Tartaglia
24 Sleep Disorders. . 205
Charles A. Czeisler, Thomas E. Scammell,
Clifford B. Saper
25 Disorders of the Eye. . 221
Jonathan C. Horton
26 Use of the Hand-Held Ophthalmoscope. . 245
Homayoun Tabandeh, Morton F. Goldberg
27 Video Library of Neuro-Ophthalmology. . 253
Shirley H. Wray
28 Disorders of Smell and Taste. . 255
Richard L. Doty, Steven M. Bromley
29 Disorders of Hearing. . 264
Anil K. Lalwani
SECTION III
DISEASES OF THE NERVOUS SYSTEM
30 Biology of Neurologic Diseases. . . . . . . . . . . . . . . . 278
Stephen L. Hauser, Stanley B. Prusiner,
M. Flint Beal
31 Seizures and Epilepsy. . . . . . . . . . . . . . . . . . . . . . . .297
Daniel H. Lowenstein
32 Cerebrovascular Diseases. . . . . . . . . . . . . . . . . . . . . 323
Wade S. Smith, S. Claiborne Johnston,
J. Claude Hemphill
33 Neurologic Critical Care, Including
Hypoxic-Ischemic Encephalopathy, and
Subarachnoid Hemorrhage. . . . . . . . . . . . . . . . . . .361
J. Claude Hemphill, III, Wade S. Smith,
Daryl R. Gress
34 Migraine and Other Primary Headache
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .376
Peter J. Goadsby, Neil H. Raskin
35 Alzheimers Disease and Other Dementias. . . . . .392
William W. Seeley, Bruce L. Miller
36 Parkinsons Disease and Other Movement
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .408
C. Warren Olanow, Anthony H.V. Schapira,
Jose A. Obeso
37 Ataxic Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . .435
Roger N. Rosenberg
38 Classification of the Spinocerebellar Ataxias. . . . .443
Roger N. Rosenberg
39 Amyotrophic Lateral Sclerosis and Other Motor
Neuron Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . .449
Robert H. Brown, Jr.
40 Prion Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .459
Stanley B. Prusiner, Bruce L. Miller
41 Disorders of the Autonomic Nervous System. . . .469
Phillip A. Low, John W. Engstrom
42 Trigeminal Neuralgia, Bells Palsy, and Other
Cranial Nerve Disorders . . . . . . . . . . . . . . . . . . . . .481
M. Flint Beal, Stephen L. Hauser
43 Diseases of the Spinal Cord. . . . . . . . . . . . . . . . . . . 490
Stephen L. Hauser, Allan H. Ropper
44 Concussion and Other Traumatic Brain
Injuries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .505
Allan H. Ropper
45 Multiple Sclerosis and Other Demyelinating
Diseases
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .513
Stephen L. Hauser, Douglas S. Goodin
46 Meningitis, Encephalitis, Brain Abscess,
and Empyema . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .533
Karen L. Roos, Kenneth L. Tyler
47 Chronic and Recurrent Meningitis. . . . . . . . . . . . .568
Walter J. Koroshetz, Avindra Nath
48 HIV Neurology. . . . . . . . . . . . . . . . . . . . . . . . . . . . .577
Anthony S. Fauci, H. Clifford Lane
49 Primary and Metastatic Tumors of the
Nervous System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 591
Lisa M. DeAngelis, Patrick Y. Wen
50 Paraneoplastic Neurologic Syndromes
and Autoimmune Encephalitis. . . . . . . . . . . . . . . .606
Josep Dalmau, Myrna R. Rosenfeld
51 Anterior Pituitary Tumor Syndromes . . . . . . . . . .615
Shlomo Melmed, J. Larry Jameson
52 Disorders of the Neurohypophysis. . . . . . . . . . . . .635
Gary L. Robertson
53 Peripheral Neuropathy. . . . . . . . . . . . . . . . . . . . . . . 648
Anthony A. Amato, Richard J. Barohn
54 Guillain-Barré Syndrome and Other
Immune-Mediated Neuropathies. . . . . . . . . . . . . .681
Stephen L. Hauser, Anthony A. Amato
55 Myasthenia Gravis and Other Diseases of
the Neuromuscular Junction. . . . . . . . . . . . . . . . . . 691
Daniel B. Drachman, Anthony A. Amato
56 Muscular Dystrophies and Other Muscle
Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .700
Anthony A. Amato, Robert H. Brown, Jr.
57 Polymyositis, Dermatomyositis, and
Inclusion Body Myositis. . . . . . . . . . . . . . . . . . . . . .730
Marinos C. Dalakas
58 Special Issues in Inpatient Neurologic
Consultation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .742
S. Andrew Josephson, Martin A. Samuels
SECTION IV
CHRONIC FATIGUE SYNDROME
59 Chronic Fatigue Syndrome. . . . . . . . . . . . . . . . . . .752
Gijs Bleijenberg, Jos W. M. van der Meer
SECTION V
PSYCHIATRIC DISORDERS
60 Biology of Psychiatric Disorders. . .. 758
Robert O. Messing, Eric J. Nestler
61 Mental Disorders. . .. 765
Victor I. Reus
62 Neuropsychiatric Illnesses in War Veterans. . 788
Charles W. Hoge
SECTION VI
ALCOHOLISM AND DRUG DEPENDENCY
63 Alcohol and Alcoholism. . 798
Marc A. Schuckit
64 Opioid-Related Disorders. . 807
Thomas R. Kosten, Colin N. Haile
65 Cocaine and Other Commonly Abused
Drugs. . 813
Nancy K. Mello, Jack H. Mendelson
66 Nicotine Addiction. . .. . 821
David M. Burns
Appendix
Laboratory Values of Clinical Importance. . .. 827
Alexander Kratz, Michael A. Pesce,
Robert C. Basner, Andrew J. Einstein
Review and Self-Assessment. . 849
Charles M. Wiener, Cynthia D. Brown,
Brian Houston
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