本書主要介紹了干細(xì)胞與再生醫(yī)學(xué)的相關(guān)研究進(jìn)展，包括干細(xì)胞的基礎(chǔ)研究與衍生研究，及其在不同生理和病理水平中的治療作用。全書共分九章，內(nèi)容包括：干細(xì)胞生物學(xué)概述、干細(xì)胞的分離與鑒定、干細(xì)胞與人類疾病、干細(xì)胞/干細(xì)胞微環(huán)境與組織再生、腫瘤干細(xì)胞、類器官、不同類型的類器官、細(xì)胞外囊泡、基因編輯與基因治療。
Chapter 1 Introduction to Stem Cell Biology 第一章 干細(xì)胞生物學(xué)概述
1 Stem Cell Research Timeline--Highlights
1.1 Stem Cell Research History
1.2 The Turning Point in Stem Cell Therapy
2 Introduction of Regenerative Medicine and Stem Cells
3 Types and Origin of Stem Cell
3.1 Stem Cell Classification Based on Differentiation Potential
3.2 Stem Cell Classification Based on Origin
4 Stem Cells and Their Niches
5 Application of Stem Cells
5.1 Stem Cells Used in Regenerative Medicine
5.2 Stem Cells for Drug Screening and Development in Laboratory
5.3 A Muhidisciplinary Field
6 Challenges and Requirements
Supplement
References
Chapter 2 Isolation and Identification of Stem Cells 第二章 干細(xì)胞的分離與鑒定
1 Embryonic Stem Cells
1.1 Genetic Modification Approaches and Potential Applications
1.2 Methods for Genetic Manipulation
2 Mesenchymal Stem Cells
2.1 Mesenchymal Stem Cells Derived from Human Adipose Tissue
2.2 Mesenchymal Stem Cells from Human Bone Marrow
3 Induced Pluripotent Stem Cells
3.1 Integrating Vectors
3.2 Non-DNA Reprogramming
4 Aduit Neural Stem Ceils
4.1 Neural Stem Cells：Origins and Functions
4.2 AduIt Brains Can Generate New Neurons
4.3 AduIt Neural Stem Cells：Implications for Therapy
5 Experimental Method
5.1 Materials
5.2 Methods
Supplement
References
Chapter 3 Stem Cells and Human Diseases 第三章 干細(xì)胞與人類疾病
1 Stem Cell Therapy for Neurological Disorders
1.1 Neural Stem Cells
1.2 Hematopoietic Stem Cells
1.3 Mesenchymal Stem Cells
2 Stem Cell Therapy in Heart Diseases
2.1 Stem Cell—Based Therapies
2.2 Brief Summary
3 Stem Cell Therapy in Diabetes Mellitus
3.1 B-Cell Replacement
3.2 Embryonic Stem Cells
3.3 Induced Pluripotent Stem Cells
3.4 Mesenchymal Stem Cells
3.5 Brief Summary
4 Stem Cell Therapy in Osteoarthritis
4.1 Stem Cell Therapy
4.2 Route of Administration
5 Stem Cell Therapy in Wound Healing
5.1 Stages of Wound
5.2 Chronic Wounds
5.3 Types of Stem Cells
5.4 Brief Summary
Supplement
References
Chapter 4 Stem Cell／Stem Cell Niche and Tissue Regeneration 第四章 干細(xì)胞／干細(xì)胞微環(huán)境與組織再生
1 Introduction to Stem Cell Niche
1.1 Definition
1.2 Components of the Niche
1.3 Niche Factors
1.4 Recap
2 Introduction to Tissue Engineering for Regeneration Medicine
2.1 Manipulating of the Niche for Regenerative
2.2 The Design of Stem Cell Niche
2.3 Synthetic Niches in Vivo
2.4 Ligand Immobilization
2.5 Tissue Engineering
2.6 Scaffold
2.7 Question
Supplement
Rerefences
Chapter 5 Cancer Stem Cells 第五章 腫瘤干細(xì)胞
1 Introduction to Cancer Stem Cells
1.1 Definition
1.2 Characteristics
1.3 Mechanism of Cancer Stem Cell Resistance to Therapy
1.4 Origin of Cancer Stem Cells
1.5 Characterize Cancer Stem Cells
1.6 Cancer Stem Cells Markers
1.7 Isolation of Cancer Stem Cells
1.8 The Correlation Between Cancer Stem Cells.Epithelial-Mesenchymal Transition and Vasculogenic Mimicy Formation
2 The Cancer Stem Cell Niche
2.1 Niche Components
2.2 Niche Fartots
2.3 Cancer Stem CeUs Derived from Mouse Induced Pluripotent Stem Cells When Exposed to a Malignant Niche
2.4 Importance of Cancer Stem Cell Niche
3 Challenges and Approaches in Cancer Stem Ceils Research
3.1 Challenges
3.2 Approaches in Cancer Stem Cells Research
Supplement
References
Chapter 6 Organoids 第六章 類器官
1 Introduction to Organoids
1.1 Definition
1.2 Development of Organoids
1.3 Origin of Organoids
1.4 The Culture of Organoids
1.5 The Composition of Organoids
1.6 Identification of Organoids
1.7 The Comparison of Organoids wit
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